Eduard A Struys Selected Research

alpha-hydroxyglutarate

5/2021	A Phase Ib Clinical Trial of Metformin and Chloroquine in Patients with IDH1-Mutated Solid Tumors.
1/2019	D-2-hydroxyglutaric aciduria Type I: Functional analysis of D2HGDH missense variants.
1/2017	Measurement of Oncometabolites D-2-Hydroxyglutaric Acid and L-2-Hydroxyglutaric Acid.
11/2016	A small molecule inhibitor of mutant IDH2 rescues cardiomyopathy in a D-2-hydroxyglutaric aciduria type II mouse model.
4/2013	Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria.
3/2010	Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria.
10/2005	Mutations in phenotypically mild D-2-hydroxyglutaric aciduria.
9/2005	Phenotypic heterogeneity in the presentation of D-2-hydroxyglutaric aciduria in monozygotic twins.
2/2005	Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria.
8/2004	Measurement of urinary D- and L-2-hydroxyglutarate enantiomers by stable-isotope-dilution liquid chromatography-tandem mass spectrometry after derivatization with diacetyl-L-tartaric anhydride.

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Eduard A Struys Research Topics

Disease

12	2-Hydroxyglutaricaciduria 01/2019 - 07/2003
9	Pyridoxine-dependent epilepsy 01/2021 - 08/2007
7	Seizures (Absence Seizure) 01/2017 - 10/2007
6	Glioma (Gliomas) 05/2021 - 03/2011
6	Neoplasms (Cancer) 05/2021 - 04/2013
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022 - 01/2018
3	Epilepsy (Aura) 01/2021 - 07/2010
3	Brain Diseases (Brain Disorder) 05/2009 - 09/2005
2	Chondrosarcoma 05/2021 - 10/2013
2	Intellectual Disability (Idiocy) 01/2021 - 01/2017
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017 - 10/2013
2	Guanidinoacetate methyltransferase deficiency 01/2017 - 02/2004
1	Cholangiocarcinoma 05/2021
1	Drug Resistant Epilepsy 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2021
1	Carcinogenesis 01/2020
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2019
1	Leukemia 10/2019
1	Rheumatoid Arthritis 10/2019
1	Crohn Disease (Crohn's Disease) 01/2018
1	Ulcerative Colitis 01/2018
1	Infections 12/2017
1	Cysts 06/2017
1	Brain Neoplasms (Brain Tumor) 06/2017
1	Movement Disorders (Movement Disorder) 01/2017
1	Alzheimer Disease (Alzheimer's Disease) 01/2017
1	Cardiomyopathies (Cardiomyopathy) 11/2016
1	Disease Progression 09/2014
1	Pyridoxamine 5-Prime-Phosphate Oxidase Deficiency 05/2014
1	Infantile Epileptic-Dyskinetic Encephalopathy 05/2014
1	Thyroid Neoplasms (Thyroid Cancer) 10/2013
1	Melanoma (Melanoma, Malignant) 10/2013
1	Molybdenum cofactor deficiency 11/2012
1	Coma (Comas) 06/2011
1	Prostatic Neoplasms (Prostate Cancer) 05/2010
1	Hypogonadism (Hypergonadotropic Hypogonadism) 05/2010

Drug/Important Bio-Agent (IBA)

11	alpha-hydroxyglutarateIBA 05/2021 - 01/2004
11	EnzymesIBA 10/2019 - 02/2004
10	Oxidoreductases (Dehydrogenase)IBA 01/2019 - 02/2005
9	Pyridoxine (Pyridoxin)FDA LinkGeneric 11/2014 - 10/2007
7	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 05/2021 - 03/2011
7	Biomarkers (Surrogate Marker)IBA 01/2021 - 08/2007
5	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 08/2003
5	allysineIBA 07/2010 - 08/2007
4	Amino Acids FDA Link 01/2022 - 06/2011
3	Lysine (L-Lysine)FDA Link 01/2021 - 11/2014
3	AcidsIBA 08/2017 - 03/2006
3	Phosphates (Orthophosphate)IBA 06/2017 - 06/2011
3	HomocysteineIBA 10/2005 - 08/2003
2	Hypoglycemic Agents (Hypoglycemics)IBA 05/2021 - 06/2011
2	Pharmaceutical PreparationsIBA 01/2021 - 10/2019
2	Arginine (L-Arginine)FDA Link 01/2018 - 11/2014
2	Glutamic Acid (Glutamate)FDA Link 12/2017 - 06/2017
2	Glutamine (L-Glutamine)FDA Link 12/2017 - 06/2017
2	Proteins (Proteins, Gene)FDA Link 08/2017 - 02/2005
2	Anticonvulsants (Antiepileptic Drugs)IBA 07/2010 - 10/2007
2	CreatinineIBA 07/2010 - 04/2008
2	S-AdenosylhomocysteineIBA 10/2005 - 08/2003
1	Circulating Tumor DNAIBA 05/2021
1	Metformin (Glucophage)FDA LinkGeneric 05/2021
1	Antimalarials (Antimalarial Agents)IBA 05/2021
1	Chloroquine (Aralen)FDA LinkGeneric 05/2021
1	marizomibIBA 01/2021
1	HomoharringtonineIBA 01/2021
1	Teniposide (VM 26)FDA Link 01/2021
1	Serum-Free Culture MediaIBA 01/2021
1	Vitamin B 6IBA 01/2021
1	Histones (Histone)IBA 01/2020
1	folylpolyglutamate synthetaseIBA 10/2019
1	Folic Acid (Vitamin M)FDA LinkGeneric 10/2019
1	Methotrexate (Mexate)FDA LinkGeneric 10/2019
1	Biological ProductsIBA 10/2019
1	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2018
1	C-Reactive ProteinIBA 01/2018
1	Histidine (L-Histidine)FDA Link 01/2018
1	CarbonIBA 12/2017
1	Carnitine (L-Carnitine)FDA LinkGeneric 08/2017
1	Tyrosine (L-Tyrosine)FDA Link 08/2017
1	GuanineIBA 08/2017
1	Glucose (Dextrose)FDA LinkGeneric 06/2017
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 06/2017
1	Lactic Acid (Lactate)FDA LinkGeneric 06/2017
1	Peptides (Polypeptides)IBA 01/2017
1	Amyloid (Amyloid Fibrils)IBA 01/2017
1	glycocyamineIBA 01/2017
1	CreatineIBA 01/2017
1	Guanidinoacetate N-Methyltransferase (Guanidinoacetate Methyltransferase)IBA 01/2017
1	Citric Acid (Citrate)FDA LinkGeneric 09/2014
1	PyridoxamineIBA 05/2014
1	citrate-binding transport proteinIBA 04/2013
1	Sulfite OxidaseIBA 11/2012
1	Insulin (Novolin)FDA Link 06/2011
1	PentosesIBA 06/2011
1	PropionatesIBA 06/2011
1	NAD (NADH)IBA 07/2010
1	Testosterone (Sustanon)FDA Link 05/2010
1	Sarcosine (Methylglycine)IBA 05/2010

Therapy/Procedure

4	Therapeutics 10/2019 - 04/2009
1	Aftercare (After-Treatment) 06/2011
1	Injections 03/2011